Synthetic Organic Chemist

We are currently looking for a Synthetic Organic Chemist to join an innovative Biotechnology company based in the North East of England. As the Synthetic Organic Chemist you will be responsible for applying a wide range of techniques to prepare, isolate, and characterise target molecules to produce antibody-drug conjugates (ADCs)

This is a great opportunity for a scientist who has experience in multi-step organic synthesis in drug development to develop their skills and directly impact the overall growth of the R&D team!

1. You will work in the R&D team designing various routes to novel and known target molecules, regularly troubleshoot, and develop new synthetic strategies to implement continuous improvement.

2. You will perform purification of target molecules and characterise organic compounds using a range of analytical techniques such as HPLC, LCMS, NMR spectroscopy, IR, and UV-Vis.

3. You will perform and monitor chemical reactions necessary for preparation of compounds and synthetic intermediates at varying scales ranging from 1 milligram to 100g.

4. You will work within a multi-disciplinary team, scout novel protocols and be encouraged to provide expertise in your chemistry perspective to contribute to the innovation of new antibody-drug conjugate (ADC) technologies.

1. Relevant degree in a in a Chemistry, Organic Chemistry, Medicinal Chemistry, or related discipline. (MSc/MChem/PhD levels are advantageous)

2. Proven industry experience working in a CRO in a synthesis / characterisation role targeting molecules through multi-step synthesis.

3. A working knowledge and practical experience with purifying complex mixtures through a range of purification techniques (HPLC, chromatography), as well as NMR, and LCMS for characterisation.


Key Words: Chemistry | Organic | Synthetic Chemistry | Organic Chemistry | Medicinal Chemistry | ADC | Antibody-Drug Conjugate | HPLC | CRO | NMR | LCMS | Synthesis | Multi-step synthesis | Cytotoxicity | Drug Development | Analytical | Peptide Synthesis | Contract Research Organisation | Biotechnology | Protein Purification | MSc | PhD | Method Development